Bonusan's CPNI-13D has been developed for people who are constantly in the fight/flight state and could use some support. It contains valerian, with associated relaxing properties. It also contains two types of standardized sage extracts. It also contains adrenal gland concentrate, which enhances the bioavailability of this supplement. Directions for use: Unless otherwise advised, it is recommended to take 2-3 capsules daily as soon as possible after your last meal, preferably around 8 p.m.